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Join Dr Sanjeev Goel, as we explore the cutting edges of medical knowledge to ”BE PEAK NOW”
Episodes
4 days ago
4 days ago
They say aging is just a part of life, but have you ever wondered if it really has to be? What if getting older isn’t just something we accept but something we could actually treat?
In this riveting episode of Peak Human Labs Podcast, Dr. Sanjeev Goel, sits down with Dr. Aubrey de Grey, a trailblazing biomedical gerontologist and Chief Science Officer of the SENS Research Foundation. They dive deep into the revolutionary idea of treating aging as a medical condition. They explore how damage accumulates in our bodies over time and discuss the groundbreaking medical advancements that could extend our healthy lifespans. Dr. de Grey sheds light on the crucial need for investing in underfunded research and shares insights into the future of longevity science. Tune in and envision a future where health and longevity are not just aspirations but achievable realities!
Click HERE to sign in for Dublin Longevity Declaration.
Key Takeaways
- Aging as a medical condition versus a natural process
- Mechanisms of damage accumulation in the body
- Concept of "longevity escape velocity"
- Role of epigenetic changes in aging
- Importance of comprehensive interventions targeting different types of damage
- Current state of therapies for extending human lifespan
- Economic implications of aging therapies and preventative medicine
- Research on retroviruses and chronic infections in relation to aging
- Innovative therapies such as hyperbaric oxygen therapy and therapeutic blood exchange
- The significance of personalized health approaches and the microbiome's impact on longevity
In This Episode:
- [00:00:00] Introduction to longevity research
- [00:00:51] Guest introduction
- [00:01:17] Personal connection
- [00:02:04] Dr. de Grey's background
- [00:03:14] Early research stages
- [00:04:05] Understanding aging as a machine
- [00:05:22] Accumulated damage mechanism
- [00:06:15] Comprehensive medical control
- [00:07:13] Categories of damage
- [00:07:55] Wear and tear concept
- [00:09:20] Epigenetic changes discussion
- [00:11:31] Partial reprogramming concept
- [00:13:30] Addressing multiple mechanisms
- [00:14:31] Longevity escape velocity
- [00:15:43] Initial pushback on longevity ideas
- [00:17:51] Positive outlook on aging research
- [00:19:51] The future of longevity research
- [00:20:54] Funding disparities in research
- [00:21:10] Business models in longevity research
- [00:21:58] Combining existing therapies
- [00:23:47] Current longevity therapies
- [00:24:56] Caloric restriction vs. drugs
- [00:25:36] Dublin Longevity Declaration
- [00:26:39] Community building through conferences
- [00:28:09] Anticipating longevity breakthroughs
- [00:29:12] Access to longevity therapies
- [00:30:58] Epigenetic clocks and age reversal
- [00:32:24] Retroviruses and aging
- [00:34:56] Persistent viral infections
- [00:37:24] Hyperbaric oxygen therapy
- [00:37:49] Therapeutic blood exchange
- [00:39:37] Discussion on active ingredients
- [00:40:41] Bone marrow transplant experimentation
- [00:42:09] Health benefits of bone marrow transplants
- [00:43:05] Personal health practices
- [00:43:55] Advice for maximizing healthy lifespan
- [00:45:01] Microbiome and longevity
Notable Quotes
- [00:03:14] "The idea that anyone could ever think that aging was just something we should accept has never made any sense to me at all." — Dr. Aubrey de Grey
- [00:14:31] "I believe we need to get to about 20 years of postponement of the health problems of late life, which I think we might be able to achieve in the next 12 to 15 years." — Dr. Aubrey de Grey
- [00:25:36] "Not only are they my favorite parts of the year, but also they are absolutely the fulcrum, the centerpiece of all of my community building effort." — Dr. Aubrey de Grey
- [00:43:36] "I can eat exactly what I like and nothing ever happens, and I don't even need to do any exercise and I still stay fit, so you know, don't do as I do, do as I say." — Dr. Aubrey de Grey
- [00:43:55] "Everybody's metabolism has its own strengths and weaknesses, and so honestly, the only generic advice that I feel that one can give in terms of maximizing one's healthy lifespan is to pay close attention to your body." — Dr. Aubrey de Grey
- [00:44:28] "I honestly can see a strong argument for just recommending to absolutely everybody that they should eat gluten-free food for like a fortnight, just to see whether they feel different." — Dr. Aubrey de Grey
Our Guest
- Dr. Aubrey de Grey is a biomedical gerontologist and founder of the LEV Foundation, focused on repairing aging-related cellular damage. Based in Silicon Valley, he earned his BA in computer science and Ph.D. in biology from the University of Cambridge. His research targets the characterization and repair of aging damage. A Fellow of the Gerontological Society of America and the American Aging Association, he advises numerous journals and organizations and is a sought-after speaker at scientific and public events.
Resources and Links
Peak Human Labs
- https://www.youtube.com/@peakhumanlabs/videos
- https://www.peakhuman.ca/
- https://www.instagram.com/peakhumanlabs/?hl=en
- https://open.spotify.com/show/5hx9R37ElxgzCrBccRWoHd?si=8atK0n82QbeL3DWg5-vjvg&nd=1&dlsi=ce0f77aa4f304724
Dr. Sanjeev Goel
Dr Aubrey de Grey
Friday Aug 02, 2024
Friday Aug 02, 2024
Dr Goel interviews Dr Steph about this remarkable C:15 fatty acid called Fatty 15
To get your 20% discount on Fatty15 click here
In this fascinating conversation with Dr. Steph, we delve into the discovery of an essential fatty acid, C15:0 pentadecanoic acid, and its profound impact on health and aging! Dr. Steph shares about her journey in creating Fatty15, and how her research in the navy dolphin’s health led to the revelation that dolphins with higher levels of C15:0 experienced healthier aging, similar to humans. This odd-chain saturated fat, once overlooked due to a bias against all saturated fats, has shown to be crucial in preventing chronic inflammation, fatty liver disease, and potentially Alzheimer's disease. While the primary source of C15:0 for humans is whole dairy fat, the conversation also touches on the implications for vegans and the need for supplementation. Furthermore, C15:0's role in cellular integrity and its potential to combat various diseases, including cancer, is discussed. The interview also explores the upcoming availability of at-home C15:0 tests and the importance of maintaining adequate levels for overall health. Dr. Steph highlights the ongoing research into C15:0's benefits for brain health and its potential applications in canine longevity. The discussion concludes with an emphasis on the importance of this fatty acid, not just for humans but for our mammalian counterparts as well. You can discover more about C15:0 and the Fatty15 supplement at an DiscoverC15.com and Fatty15.com
Wednesday May 29, 2024
Wednesday May 29, 2024
Join Dr. Sanjeev Goel and seasoned biohacker Sol-Pal John Bejarano in a deep dive into the world of biohacking. Sol-Pal shares his inspiring journey of age reversal, motivated by his father's stroke. Discover the crucial role of education, diet, supplements, and stress management in aging gracefully. Sol-Pal's approach tackles the 12 Hallmarks of Aging through a personalized regimen, offering practical tips for stress management and health optimization. Learn about Sol-Pal's meticulous tracking methods and how they enhance health without sacrificing productivity. Dive into the world of biohacking with this insightful discussion!
TIMESTAMPS:
00:00 - Intro
00:40 - Background and motivation
05:24 - Starting the biohacking journey
06:17 - Addressing genomic instability
08:01 - Managing chronic stress
11:46 - Tracking routines and staying productive
13:39 - Addressing telomere attrition
15:05 - Intro to magnesium
17:30 - Types of magnesium and dosage
20:26 - Tracking biomarkers and biological age
23:30 - Balancing diet for longevity
26:04 - Success stories in biohacking
30:01 - Functional medicine doctor recommendation
30:19 - Future of biohacking movement
32:28 - Biohacking worldwide
34:43 - Importance of coaching
35:36 - Starting your biohacking journey
37:17 - Basic supplements
41:58 - Precision supplements
42:40 - Closing remarks
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE TODAY: https://bit.ly/PeakHumanLabs
Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Friday May 17, 2024
Friday May 17, 2024
Join Dr. Sanjeev Goel and Dr. Anil Maheshwari in a deep dive into cardiovascular health, discussing key risk factors, advanced lipid tests, and the importance of individualized care. Learn about cholesterol markers, genetic influences, and lifestyle modifications that can lower cardiovascular risk. Gain insights into the complexity of heart health and the latest advancements in cardiovascular care.
TIMESTAMPS:
00:00 - Intro
01:21 - Advocating for Your Health
03:45 - Ethnicity and Cardiovascular Risk
05:05 - Family History and Cardiovascular Risk
07:05 - LDL (Low-Density Lipoprotein)
10:32 - LDL Guidelines
12:51 - Oxidized LDL
14:03 - HDL (High-Density Lipoprotein)
16:33 - Total Cholesterol to HDL Ratio
19:54 - Triglycerides and Non-HDL Cholesterol
21:49 - Apolipoprotein B (APO B) and Lipoprotein A (Lp(a))
24:21 - Lipoprotein A (continued), Genetic Risk, and Medication Considerations
30:13 - High Sensitivity CRP (hs-CRP) and Inflammation
33:15 - Additional Tests and Medication Options
36:02 - Conclusion
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE TODAY: https://bit.ly/PeakHumanLabs
* Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Tuesday May 07, 2024
Tuesday May 07, 2024
Join Dr. Sanjeev Goel in discovering the transformative power of heart rate variability (HRV) with Dr. Torkil Færø as he delves into his book, "The Pulse Cure." Learn how personalized approaches and Garmin's tracking technology can optimize your HRV. Dr. Færø shares insights on improving sleep, diet, and exercise for better health. Hear success stories and explore the future of preventive medicine through HRV customization. Tune in to this episode for actionable tips on enhancing your well-being and longevity.
TIMESTAMPS:
00:00 - Intro
01:36 - Intro of Dr. Torkil Færø
03:24 - Background of Dr. Færø
05:51 - Importance of Heart Rhythm
08:35 - Tracking HRV
09:55 - New Wearable Technologies
10:51 - Aging and HRV
12:57 - Impact of Alcohol on HRV
14:48 - Success Stories
16:54 - Future Research
18:04 - Understanding Stress and Recovery
21:51 - Utilizing Technology for Health Monitoring
29:25 - Importance of Rest and Recovery
34:33 - Conclusion
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE TODAY: https://bit.ly/PeakHumanLabs
* Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Tuesday May 07, 2024
Tuesday May 07, 2024
In this video, Dr. Sanjeev Goel and Vyom Goel delve into the topic of mental health, focusing on the importance of mindfulness. They discuss how mindfulness isn't about stopping thoughts but rather being aware of them without judgment. They guide viewers through a simple mindfulness exercise, highlighting the benefits of taking a moment for oneself. Whether you're new to mindfulness or looking to deepen your practice, this episode offers practical tips and techniques to help you on your journey to greater mental well-being.
TIMESTAMPS:
00:00 - Intro
00:15 - Importance of Mindfulness
01:52 - Challenges in Practicing Mindfulness
04:19 - Mindfulness Exercise Demonstration
06:26 - Conclusion
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE TODAY: https://bit.ly/PeakHumanLabs
* Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Thursday May 02, 2024
Thursday May 02, 2024
Join Dr. Sanjeev Goel from Peak Human Labs as he explores the potential of liquid biopsies for early cancer detection. Learn how these blood tests could revolutionize cancer screening by identifying cancerous signs before tumors develop. Discover the benefits, limitations, and future possibilities of this cutting-edge technology.
TIMESTAMPS:
00:00 - Introduction
00:15 - Multi-Cancer Detection Test
01:45 - Potential Benefits and Drawbacks
02:25 - Accuracy and False Positives
03:38 - Prostate Specific Antigen Test
04:45 - Future of Cancer Screening
05:42 - Availability and Cost
06:14 - Conclusion
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE TODAY: https://bit.ly/PeakHumanLabs
******************** Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Sunday Apr 28, 2024
Sunday Apr 28, 2024
Join Dr. Sanjeev Goel and Dr. Sanjiv Chopra, a renowned hepatologist and Harvard Medical School professor, as he delves into the realms of leadership and purpose. Dr. Chopra shares profound insights from his own journey, stressing the significance of aligning actions with personal purpose. Discover the four pillars of happiness he advocates for meaningful relationships, forgiveness, altruism, and gratitude. Dr. Chopra's discussion offers practical wisdom for those seeking fulfillment and clarity in their lives. He also touches on his forthcoming book, "Letters to a Young Doctor," which explores alternative career paths for physicians. Dive into this engaging conversation filled with valuable life lessons and professional guidance.
TIMESTAMPS:
00:00 - Intro
01:20 - Dr. Sanjiv Chopra's background
03:54 - Dr. Chopra's journey into leadership
07:03 - Discovering purpose in life
13:02 - Importance of defining personal purpose
16:19 - Example of defining purpose (Elena Sotoor)
17:53 - Advice for finding purpose
18:05 - Importance of gratitude
19:00 - Purpose in life
21:30 - Story of Papa Jaime
26:44 - Breakthroughs in Medicine
34:01 - Gut microbiome
38:03 - Safe amount of alcohol
38:10 - Letters to a Young Doctor (Book)
39:12 - Abraham Verghese and "The Covenant of Water"
40:02 - Inspiring stories of Physicians turned Authors
40:49 - Advice to young doctors
42:54 - Lifelong learning
47:08 - Future of Medicine
52:34 - Hope and Aging
57:21 - Conclusion
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE ON YOUTUBE: https://bit.ly/PeakHumanLabs
Link to Study https://jamanetwork.com/journals/jama... 📚
Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Friday Apr 05, 2024
Friday Apr 05, 2024
Join Dr. Sanjeev Goel in an interview with Dr. Raghav Sehgal, a PhD student at Yale and expert in epigenetic clocks. Discover how Dr. Sehgal's research sheds light on aging, from predicting chronological age to understanding the pace of aging and mortality risk. Learn about the concept of "systems age" and how different organs age at varying rates, impacting disease prevalence. Explore the potential for personalized treatments based on these findings. Dr. Sehgal also discusses the impact of lifestyle factors like diet and exercise on reversing epigenetic aging, offering practical insights for a healthier, more youthful life.
TIMESTAMPS:
00:00 - Introduction
01:05 - Background and Entry into Epigenetic Clocks
09:03 - History of Epigenetic Clocks
17:00 - Systems Age: Measuring Aging in 11 Organs
19:02 - Importance and Significance of Systems Age
20:04 Aging Clusters
22:26 Cardiovascular Disease Clusters
24:56 Impact of Alcohol on Aging
27:52 Reversibility of Epigenetic Clocks
30:11 Impact of Diet on Aging
35:43 Personalized Recommendations
38:51 Exercise and Longevity
39:31 Availability of Systems Clock
40:05 Future Projects
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
Subscribe on Youtube: https://bit.ly/PeakHumanLabs
Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF
Wednesday Mar 27, 2024
Wednesday Mar 27, 2024
Join Dr. Sanjeev Goel and Carmelia Ray as they delve into the world of popular diets. From intermittent fasting to the South Beach Diet, Atkins, and the Raw Food Diet, they provide insights, tips, and considerations for each approach. Discover the pros and cons, the science behind them, and practical strategies for incorporating healthier eating habits into your lifestyle. Whether you're curious about weight loss, metabolic health, or simply optimizing your well-being, this podcast episode offers valuable information to help you make informed choices about your diet.
******************** TIMESTAMPS:
00:00 - Intro
00:28 - Discussion on different diets
03:13 - Intermittent Fasting
10:38 - South Beach Diet
12:13 - Atkins Diet
16:22 - Raw Food Diet
20:50 - Closing Remarks
Visit our website: https://peakhuman.ca
Shop here: https://peakhuman.ca/shop/
SUBSCRIBE TODAY: https://bit.ly/PeakHumanLabs
******************** Link to Study https://jamanetwork.com/journals/jama...
📚 Purchase the Peak Longevity Prediction Pack 📚
→ https://peakhuman.ca/product/peak-lon...
📚 PURCHASE DR. SANJEEV GOEL'S BOOK "The Top 10 Must Do Peak Human Biohacks of 2023"📚
→ iBooks: https://books.apple.com/ca/book/top-1...
→ Kobo: https://www.kobo.com/ca/en/ebook/the-...
→ Amazon - https://www.amazon.com/dp/B0C1J2N1YF